Volume9,Issue6,Article22

Isolation and Characterization of Phytol from Justicia gendarussa Burm. f.-An Anti-Inflammatory Compound

Phatangare N D1*, Deshmukh K K1, Murade V D2, Hase G J1, Gaje T R

1S.N.Arts, D.J.M.Commerce and B.N.S.Science College, Sangamner, Dist: A.nagar, Maharashtra, India-422605

2Padmashri Vikhe Patil College of Arts, Science and Commerce, Pravaranagar 

Received: 24th April, 17; Revised: 27th May, 17; Accepted: 15th June, 17; Available Online:25th June, 2017 

ABSTRACT

Justicia gendarussa burm.f. has become important source of Phytol which is associated with other phenolic,terpenoids,alkaloids. Diterpenes shows anti-inflammatory activity. Phytol is a acyclic diterpene alcohol found as essential oil in aromatic plants.oil is obtained by Keshav-Naren apparatus (patent no:2343/Mum/2013/A).Phytol separated from other oil part by fractional distillation. It separated at 204-2080C.Characterization of Phytol carried out by IR,NMR,and mass spectrometry. Phytol shows potent as Anti-inflammatory activity by releasing histamine (26.92%), serotin and bradykinin (49.90%), and prostaglandin (68.03%) as compared to standard (Dicolfenac 5mg/kg).    

Keywords: Keshav-Naren apparatus, Justicia gendarussa burm.f. ,Anti-inflammatory activity etc.

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International Journal of Pharmacognosy and Phytochemical Research