Molecular Modeling and Docking Analysis Of Callosobruchus maculates Cytochrome B Proteins with Bio Active Compound Phytolfrom Glinus lotoides and Synthetic Pesticide Pirimiphos-Methyl

Adline Jennefa Daniel1,2, Gunasekaran C2* 1Madras Christian College, Chennai2Bharathiar University, Coimbatore 

Received: 23rd March, 17; Revised 1st June, 17, Accepted: 15th June, 17; Available Online:25th June, 2017 


Cytochrome b is a component of respiratory chain complex III, also known as bc1 complex or ubiquinol-cytochrome c reductase. These complexes are involved in electron transport and generation of ATP and thus play a vital role in electron transport chain.  Phytol is a phytochemical derived from ethyl acetate extract of Glinus lotoides. Cytochrome b modeled and the structure was used for In-silico binding efficiency and comparative analysis of cytochrome b with Phytol and synthetic pesticide were showed good docking score and binding affinity when compared to control. This study will be used in broad screening of the protein in the respiratory process and can be further implemented in designing pest control. 

Keywords: Homology modeling, Cytochrome b, Ramachandran plot, Docking.

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International Journal of Pharmacognosy and Phytochemical Research