International Journal of

Pharmacognosy and Phytochemical Research

e-ISSN: 0975 4873

p-ISSN: 2961-6069

Peer Review Journal

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1. Evaluation of the Ethanolic Extract of Ficusvirens Bark Carrageenan-Induced Anti-Inflammatory Activity in Swiss Albino Mice
Orupula Jayalakshmi, Panjwani Simran, Soujanya, Juthuga Sridevi
The purpose of this study was to investigate if an ethanolic extract of Ficusvirens bark may potentially reduce inflammation in mice that had been caused by carrageenan. 60 minutes before to receiving an injection of 0.1 mL of 1% carrageenan, Swiss albino mice were given oral treatments with normal saline (as the control group) and Ficusvirens extract (200 and 400 mg/kg). Paw volume was measured before, one, two, and three hours after the carrageenan injection. The Mean was used to express the findings ±SEM and the statistical significance of group differences were examined using One Way Analysis of Variance (ANOVA) and Dunnett’s test, respectively. The mice’s paw edoema was triggered by the sub plantar injection of carrageenan and was time-dependent. Ficusvirens extract (100 and 200 mg/kg) given orally at 1, 2, and 3 hrs after carrageenan injection decreased paw swelling dose-dependently. The results of the current study lead us to the conclusion that Ficusvirens extract has great anti-inflammatory effects on mice.

2. Correlation Between Body Mass Index and Antibody Titers Post COVID-19 Vaccination: Exploring the Impact of Heartfulness Meditation
Mamta Dubey, R.B.Kamal, Poonam Gupta, Kavita Chawla, Reena Sachan, Saraswati J Yadav, Enam Ahmad, Rakesh Kumar Pathak
Background: The global development and distribution of vaccinations against the COVID-19 pandemic has been accelerated. If we want our vaccines to work as well as possible, we need to know what makes the immune response to them tick. One such factor that determines immunological response is body mass index (BMI), which is a measure of how much fat a person has. Heartfulness meditation, a practice that promotes emotional well-being, has also shown promise in enhancing immune function. This study aims to explore the correlation between BMI and antibody titers post COVID-19 vaccination and investigate the potential impact of Heartfulness meditation on this relationship. Methods: A cross-sectional study was conducted on a sample of individuals who received the COVID-19 vaccine. BMI was calculated based on height and weight measurements. Antibody titers were assessed using standardized laboratory tests. Participants were categorized into BMI groups (normal weight, overweight, and obese) for analysis. Heartfulness meditation practice was assessed through self-report measures. Results: The study included 72 participants who had received the COVID-19 vaccine. Analysis revealed a no significant correlation between BMI and antibody titers post vaccination. The study participants fell into the category of “normal” and “underweight”. In the underweight group, neutralising antibodies were detected at 0 months (97.2098 ±4.65125), 3 months (97.8168 ±2.55290), and 6 months (98.5063 ±.80221), while in the normal body weight group, they were detected at 0 months (95.5272 ±11.40342, at 3 months (-95.4111 ±10.26813), and at 6 months (96.3005 ± 7.76224). This shows no difference in antibody titre between the different body weight. Conclusion: This study demonstrates no association between BMI and antibody titers post COVID-19 vaccination, suggesting that obesity may adversely affect the immune response. Future research should explore the underlying mechanisms and conduct longitudinal studies to evaluate the sustainability of these effects. Implementing meditation interventions alongside vaccination efforts may help optimize immune response, particularly in individuals with higher BMIs

3. Understanding the Link between Endocrine Disrupting Chemicals and Diabetes Risk
Mohd Shakir Hussain, Ajit Kumar Mishra
Introduction: An exogenous substance or chemical combination that interferes with any component of hormone action is referred to as an EDC by the Endocrine Society. EDCs can obstruct the activity and secretion of insulin as well as other pathways that control glucose homeostasis. The well-known plastic hardener bisphenol A (BPA) has a very short half-life (hours) in humans, but due to exposure on a more-or-less daily basis, detectable quantities are still detected in the majority of people in industrialized countries. T1DM development has been linked to exposure to several EDCs. Results: A meta-analysis of cross-sectional and prospective research, published in 2016, revealed that levels of dioxins, PCBs, organochloride insecticides, and BPA were significantly correlated with the prevalence of diabetes in the cross-sectional setting. To find out whether foetal and prenatal exposure to EDCs causes obesity and later type 2 diabetes, big prospective studies are required. Conclusion: Several epidemiological studies have suggested an association between EDC and diabetes. Higher exposure to diabetogenic contaminants is an important factor. Further work is needed to validate the association between EDC and diabetes and to more accurately quantify differences in exposure.

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