Volume3,Issue4

Tephrosia purpurea L. belongs to the Family Fabaceae. It is one of the most important plants used in the indigenous system of medicine. To study the anti-inflammatory activity of 50 per cent alcoholic root extract of T. purpurea using Carrageenan induced model. Anti-inflammatory activity of root of T. purpurea was studied, in which inflammation was induced by injecting 0.1ml of 1 per cent Carrageenan in to the sub plantar side of the left hind paw. Test drugs were administered in a dose of 5, 10 and 20 mg/kg B.W. one hour before commencing the experiment. The anti-inflammatory activity was assessed by determining and comparing the paw volume (ml) in the test drug group with that of the vehicle control group. Dichlofenacsodium 5 mg/kg B.W. was used as a reference drug. Inflammation in the root of T. purpurea treated animals was found to be significantly less compared to vehicles control animals. Dichlofenacsodium (5 mg/kg B.W.) produce significant reduction in inflammation when compared to control group. Root extract of T. purpurea produced significant anti-inflammatory activity. Our results suggest that all the root extract of T. purpurea possess significant anti-inflammatory activity. Among the three doses of T. purpurea 20 mg/kg B.W. showed maximum activity.

In the present study, the phytochemical screening of Cassia occidentalis Linn. were performed in petroleum ether, chloroform and methanolic extracts. The chloroform and methanolic extracts of both flower and seed were found to contain flavonoids, alkaloids, phenolics/tannins, steroids, glycosides and anthraquinones. The antioxidant potential of flowers and seeds in different solvent extracts were evaluated by various biochemical assays namely, DPPH (2, 2’- diphenyl-1-picrylhydrazyl) radical scavenging activity, reducing power activity. Their SC50 and EC50 values were determined to evaluate the therapeutic potential, in which seeds were found to have higher antioxidant activity revealed by lower SC50 and EC50 value. The total phenol, flavonoid, flavonol and tannin content were determined for both parts to study the free radical scavenging property. The seeds were found to have higher antioxidant activity when compared to flowers in various solvent extracts indicating their pharmacological property.

Cyamopsis tetragonoloba is widely consumed by people and it is found to have varied medicinal values. Cyperus rotundus is also found to have different medicinal properties. Cyamopsis tetragonoloba fruit and Cyperus rotundus rhizome were therefore analyzed by GC-MS analysis to assess their phytochemical constituents. The ethanolic extract of C. tetragonoloba fruit showed the presence of thirty four phytochemical constituents. The major phytochemical compounds were mome inositol, ethyl alpha-d-glucopyranosidend stigmasterol. The ethanolic extract of C. rotundus showed the presence of twenty two phytochemical constituents. The major phytochemical compounds were 7- isopropenyl-1,4a-5,6,7,8-hexahydro-3H-naphthalen-2-one, zierone and (+)-cis-longipinan.

Ammania baccifera Linn (Lythraceae)is popular traditional medicinal plant in rural India. The study was intended to evaluate the anti inflammatory potential Alcoholic and aqueous extracts of ammania baccifera Linn (Lythraceae) against acute inflammation which was induced by inflammogens like carageenan, histamine and 5HT. The extracts were administered in a dose of 250 and 500 mg/kg to the animals oraly. Both the extracts shown dose dependent decrease in the paw edema in tested animals. In carageenan induced inflammation the extracts significantly (p<0.05) inhibit the paw edema and rectifies the deranged biochemical parameters. The extracts are also able to supress the inflammation induced by mediators like histamine and 5HT. Among the extracts alcoholic extracts show more profound effect than the aqueous effect. This gives rational for the use of this plant in the traditional medicines.

Desmodium gangeticum (L.) DC. (Family: Fabaceae) is an important medicinal herb commonly known as Salparni. It is widely used in Ayurveda formulations for the treatment of various ailments and neurological disorders. Pharmacognostic evaluation including examination of morphological and microscopical characters, ash values, extractive values, powder characteristic, bitterness value, foreign matter and HPTLC profile was carried out to set them as diagnostic indices for the identification/ validation of the raw material and standardization of its formulations in fixing quality control parameters.